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Which of the following is one of the key factors that differentiate major depression from periods of sadness that everyone experiences?
(A) Major depression is indicated by specific changes in the brain.
(B) People who experience major depression are sad for longer than two weeks without an obvious cause.
(C) Individuals diagnosed with major depression experience sadness along with episodes of heightened emotions and mania.
(D) All mood disorders, like major depression involve tolerance and withdrawal of controlled substances.
(E) Normal periods of sadness are much less intense than the sadness associated with major depression.